Heck Transformations of Biological Compounds Catalyzed by Phosphine-Free Palladium

Heterogeneously Catalyzed Phosphine-Free Heck Cross-Coupling Reaction of Aryl Halides with Reusable Palladium(II) Schiff Base Complex

O acoplamento entre haletos de arila e terminais alceno (reação de Heck) foi investigado na presença de catalisadores de paládio (II) suportados em poliestirenos contendo bases de Schiff. O catalisador é estável frente ao ar e umidade, e tem atividade catalítica significativa nas reações de acoplamento cruzado de Heck sob condições normais. Vários haletos de arila e alcenos terminais foram faci...

Palladium-Catalyzed Synthesis and Transformations of Organometallic Compounds

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Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.

Palladium-catalyzed intermolecular Heck reaction of alkyl halides.

Intermolecular Heck reaction of common alkyl halides, a longstanding problem in palladium catalysis, is realized with a simple Pd/dppf catalyst. Both primary and secondary alkyl halides are suitable for coupling with aromatic olefins. Single electron transfer from (dppf)Pd(0) to alkyl halide initiated the catalytic cycle and gave alkyl radicals.

Ligand-free Palladium-Catalyzed Mizoroki-Heck-type Reaction of Arylboronic Acids and Alkenes Using Silver Cation